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Dupilumab safe to continue during vaccine administration in children with AD reveals study
Dupilumab inhibits interleukin (IL)-4 and IL-13 signalling. This monoclonal antibody also acts as an immunomodulator. The current recommendation is to avoid live vaccine administration in dupilumab-treated patients.
A case series involving nine children with severe atopic dermatitis (AD) receiving measles, mumps, and rubella (MMR) vaccine with/without the varicella vaccine in dupilumab clinical trials found no emergence of side effects within four weeks after vaccination. Consequently, the researchers concluded that dupilumab is safe to continue during vaccine administration. This case report is published in Pediatric Dermatology.
In a phase 2/3 clinical trial of dupilumab involving 6-month to 5-year-old children ( subsequently participated in the LIBERTY AD PED-OLE) with moderate-to-severe atopic dermatitis, nine children (protocol deviation) received MMR vaccine with or without varicella vaccine. Five of these children received the vaccine with a ≤12-week gap after dupilumab administration, while four received it >12 weeks after discontinuing dupilumab.
Key findings from the study are:
- Nine children had severe AD at baseline.
- Five of the nine children received the MMR or MMR and varicella vaccines within a 1-7 week gap after their dupilumab administration, with treatment resuming for one child as early as two days and three children after 18-43 days.
- No serious adverse events were reported during a post-vaccination period in any children.
Concluding further, they said, In this case, a series of nine children with severe AD who received the MMR vaccine with or without varicella vaccine while being treated with dupilumab, no adverse events or infection were reported within four weeks of vaccination. Further studies are needed to investigate safety and immune response to live attenuated vaccines in dupilumab-treated patients
Sanofi and Regeneron Pharmaceuticals Inc. sponsored the study.
Reference:
Siegfried et al. A case series of live attenuated vaccine administration in dupilumab‐treated children with atopic dermatitis. Pediatric Dermatology.
BDS, MDS in Periodontics and Implantology
Dr. Aditi Yadav is a BDS, MDS in Periodontics and Implantology. She has a clinical experience of 5 years as a laser dental surgeon. She also has a Diploma in clinical research and pharmacovigilance and is a Certified data scientist. She is currently working as a content developer in e-health services. Dr. Yadav has a keen interest in Medical Journalism and is actively involved in Medical Research writing.
Dr Kamal Kant Kohli-MBBS, DTCD- a chest specialist with more than 30 years of practice and a flair for writing clinical articles, Dr Kamal Kant Kohli joined Medical Dialogues as a Chief Editor of Medical News. Besides writing articles, as an editor, he proofreads and verifies all the medical content published on Medical Dialogues including those coming from journals, studies,medical conferences,guidelines etc. Email: drkohli@medicaldialogues.in. Contact no. 011-43720751