Dexmedetomidine with Bupivacaine reduces opioid intake after cholecystectomy: Study
Among other known multimodal methods for post-operative analgesia, intraperitoneal (IP) instillation of local anesthetics with adjuvants remains the standard of care among anesthesiologists. Few editorial outlines have discussed the off-label uses of Dexmedetomidine in number of clinical scenarios. This void paved the way to determine the effects of clonidine with dexmedetomidine along with Bupivacaine for post-operative analgesia.
A recent study established that post operative opioid consumption can be reduced with the addition of dexmedetomidine to bupivacaine. This prospective study was conducted by Dr. Thottikat Kaarthika and team from Andhra Pradesh and was published in the Indian Journal of Anesthesia on 23 July 2021.
The study included 108 patients (36 in each group) of 18 to 60 years of age and grouped them into Group B, Group BD, Group BC. Group B received 20 mL of 0.5% bupivacaine, Group BD received 20 mL of 0.5% bupivacaine with dexmedetomidine 1 µg/kg and Group BC received 20 mL of 0.5% bupivacaine with clonidine 1 µg/kg.
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