Amiodarone therapy tied to increased all-cause mortality in ICD recipients: Study
Germany: The combined therapy with beta-blockers plus amiodarone has no unfavourable effect on the success of defibrillation testing compared to single beta-blockers in a "real life" cohort of ICD (implantable cardioverter defibrillator) recipients of the German DEVICE registry. The findings of the study were featured in Heart Rhythm.
The data suggested an increase in all-cause mortality with amiodarone therapy, particularly in the subgroups of patients with severely reduced left ventricular function or sinus rhythm. The rates of arrhythmic events were found to be similar in surviving patients.
Amiodarone is frequently used for antiarrhythmic therapy in ICD or CRT-D systems (cardiac resynchronization therapy defibrillator) recipients due to the lack of alternatives and owing to its antiarrhythmic potency. However, robust data on the safety and clinical utility of amiodarone therapy in these patients still need to be included. Therefore, Felix Wiedman from University Hospital Heidelberg, in Heidelberg, Germany, designed a study to evaluate the outcomes (periprocedural and post-procedural) of combined therapy with beta-blockers and amiodarone versus treatment with single beta-blockers in the recipients of ICD.
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