Angioedema risk not greater among new users of ARNI compared to users of ACE Inhibitors, ARBs
The study supports starting with sacubitril/valsartan, not switching to it in heart failure patients.
USA: An increased risk of angioedema was not seen among heart failure patients who are new users of sacubitril-valsartan (SV) compared with an ACE inhibitor or ARB users, according to findings from a propensity score–matched cohort study. The results appeared online in the January 2023 issue of JACC (Journal of the American College of Cardiology).
The researchers found an increased risk of angioedema among SV users who recently switched from ACE (angiotensin-converting enzyme) inhibitor or ARB (angiotensin-receptor-blocker) compared with new users sacubitril-valsartan.
In July 2015, sacubitril/valsartan received FDA's approval for use in patients with HFrEF (chronic heart failure with reduced ejection fraction), gaining a broader indication that includes at least some patients with HFpEF (preserved ejection fraction) in February 2021. The approvals were based respectively on findings from the PARADIGM-HF and PARAGON-HF trials.
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