Chlorhexidine gluconate pocket lavage prevents infection during high-risk cardiac implantable electronic procedures

A total of 1504 patients were included. At 12-month follow-up, the primary efficacy outcome occurred in 4 of 904 CHG (0.4%) and 14 of 600 NS (2.3%) subjects (log-rank P = .005). On multivariate analysis, use of CHG irrigation remained associated with a lower risk of infection at 1-year follow-up (Cox proportional hazard ratio [HR] 0.138; 95% confidence interval [CI] 0.04–0.45; P = .001). This effect persisted during long-term follow-up. PSM demonstrated a significant reduction in CIED-related infection for the CHG group (0.2% vs 2.5%; Cox proportional HR 0.08; 95% CI 0.01–0.59; P = .014). No adverse events were associated with the use of CHG.

CHG lavage during high-risk procedures was associated with a reduction in CIED-related infections without any adverse events reported.

Reference:

Juan Carlos Diaz, Eric D. Braunstein, Felipe Cañas, Carlos D. Matos, William H. Sauer, Jorge E. Romero. Chlorhexidine gluconate pocket lavage to prevent cardiac implantable electronic device infection in high-risk procedures. Published:August 18, 2023DOI:

https://doi.org/10.1016/j.hrthm.2023.08.015

Keywords:

Chlorhexidine, gluconate, pocket, lavage, prevents, infection, during, high-risk, cardiac, implantable, electronic, procedures, Juan Carlos Diaz, Eric D. Braunstein, Felipe Cañas, Carlos D. Matos, William H. Sauer, Jorge E. Romero, Heart Rythm