Crushed Prasugrel significantly Lowers Platelet Activity In Patients undergoing PCI: Study
When crushed Prasugrel is administered to patients with suspected STEMI, it significantly lowered the platelet activity.;
Written By : MD Bureau
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2021-07-06 05:00 GMT | Update On 2023-10-09 11:30 GMT
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When crushed Prasugrel is administered to patients undergoing Primary Percutaneous Coronary Intervention, it significantly lowered the platelet activity, according to a study published in the Journal of the American College of Cardiology.
ST-segment elevation myocardial infarction (STEMI) is the term cardiologists use to describe a classic heart attack. It is one type of myocardial infarction in which a part of the heart muscle (myocardium) has died due to the obstruction of blood supply to the area. As a treatment strategy, STEMI patients are directly taken to the cardiac catheterization laboratory to undergo mechanical revascularization. This is called Primary Percutaneous Coronary Intervention. Anti-platelet therapy is given to such patients. However, the onset of action varies according to the formulation administered.
With this background, Dr. Ashish Kumar Aggarwal carried out a study to compare the pharmacodynamic effects of prasugrel in crushed versus integral tablet formulation in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI).
The trial randomized 441 patients with suspected STEMI and they were given crushed or integral prasugrel 60-mg loading dose in the ambulance. Pharmacodynamic measurements were performed at 4 time points: before antiplatelet treatment, at the beginning and end of pPCI, and 4 h after study treatment onset. The primary endpoint was high platelet reactivity at the end of pPCI. The secondary endpoint was impact of platelet reactivity status on markers of coronary reperfusion.
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