Diabetes cuts long-term survival after surgery for infective endocarditis

The key findings of this study are as follow:

1. There were 420 patients in the trial.

2. Group I (non-diabetic patients) included 326 people, whereas Group II (diabetic patients) had 94 people.

3. The average period of follow-up was 39.3±28.1 months.

4. Short-term, 30-day, and in-hospital mortality, as well as intermediate-term (1- and 3-year) mortality, were greater in the DM group compared to the non-DM group, although not statistically significant: 11.7% vs. 7.7%, 12.8% vs. 8.3%, 20.2% vs. 13.2%, and 23.4% vs. 15.6%.

5. Long-term, 5-year mortality in the DM group was considerably greater than in the non-DM group: 30.9% vs. 16.6%.

6. Diabetes was also found to be a predictor of long-term death, according to regression analysis.

In conclusion, diabetes patients show a trend toward higher mortality after IE surgery in the short and intermediate-term, although this is not statistically significant. Usually, after more than 3 years, diabetes individuals' survival begins to decline.

Reference:

Kogan, A., Wieder, A., Frogel, J., Peled-Potashnik, Y., Raanani, E., & Sternik, L. (2022). Surgical Treatment on Infective Endocarditis: Impact of Diabetes on Mortality. Research Square Platform LLC. https://doi.org/10.21203/rs.3.rs-1379104/v1

Keywords: diabetes, infection, comorbid, cardiovascular diabetology, endocarditis, heart failure, cardiac surgery, mortality, Alexander Kogan, Research Square