Earlier onset of hypertriglyceridemia increases risk of CVD and mortality: JAHA

The study led to the following findings:

· The researchers documented 807 incident CVD events and 600 all‐cause mortality events.

·Patients with hypertriglyceridemia onset age <45 years were at greater risk than the matched controls, with hazard ratios of 2.61 for CVD, 4.69 for all‐cause mortality, 2.23 for all-cause mortality myocardial infarction, and 2.68 for stroke.

·There was a gradual decrease in risk estimates with each decade increase in the hypertriglyceridemia's onset age.

New-onset hypertriglyceridemia was shown to be associated with elevated risks for incident CVD and all-cause mortality regardless of traditional risk factors. Also, identifying hypertriglyceridemia at an earlier onset age was linked to greater CVD and all-cause mortality risk. The new‐onset hypertriglyceridemia–related CVD risk was driven mainly by increased stroke incidence among Chinese adults.

"Onset age of hypertriglyceridemia was a requisite determinant of CVD and all-cause mortality," the researchers wrote in their study. Although there is a strong association in younger onset, earlier identification and prevention targeting hypertriglyceridemia would positively influence CVD and all-cause mortality."

Reference:

Zhou H, Ding X, Yang Q, Chen S, Li Y, Zhou X, Wu S. Associations of Hypertriglyceridemia Onset Age With Cardiovascular Disease and All-Cause Mortality in Adults: A Cohort Study. J Am Heart Assoc. 2022 Oct 18;11(20):e026632. doi: 10.1161/JAHA.122.026632. Epub 2022 Oct 17. PMID: 36250656.