Low dose edoxaban beneficial in patients with atrial fibrillation ;claims study
Direct oral anticoagulants (DOACs) have become the preferred therapy for stroke prevention in atrial fibrillation (AF), current guidelines recommend DOACs over vitamin K antagonists for stroke prevention in most patients with AF . However, the inherent risk of severe bleeding, although less frequent with DOAC therapy than vitamin K antagonists, may affect the morbidity and mortality of patients.
According to a recent trial, a lower dose of edoxaban than the standard dose ,has shown great potential in treating patients with atrial fibrillation.In the recently conducted ENGAGE AF-TIMI 48 trial, the primary NCO was reduced with lower dose edoxaban regimen(LDER) versus higher dose edoxaban regimen (HDER), whereas the secondary and tertiary NCOs were similar between the 2 dosing regimens. The findings have been published in Journal of the American College of Cardiology.
"These results may aid physicians in evidence-based individualization of edoxaban dosing. However, the approved HDER remains the standard therapy among the available edoxaban dosing regimens for stroke prevention in atrial fibrillation."the research team quoted.
The objective of the present analysis of the ENGAGE AF TIMI-48 trial was to comprehensively compare the net clinical outcome (NCO) of LDER (30 mg once daily, dose reduced to 15 mg in selective patients) versus HDER (60 mg once daily, dose reduced to 30 mg in selective patients).
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