Ozone exposure linked to hypoxia and increased arterial stiffness, finds study
Ozone (O3) exposure may reduce the availability of oxygen in the body, resulting in arterial stiffening due to the body's natural response to create more red blood cells and hemoglobin, according to a study published today in JACC, the flagship journal of the American College of Cardiology.
Hypoxia is a shared pathogenesis of ozone associated diseases; therefore, we hypothesized that O3 exposure may induce changes in hypoxia-related markers, leading to adverse cardiovascular effects.
“Researchers found that even brief exposure to elevated ozone levels reduced blood oxygen saturation, triggered hypoxia-related biomarkers, and increased arterial stiffness, highlighting the novel connection between ozone exposure and arterial stiffness, demonstrated through comprehensive biomarker analysis in a high-altitude setting,” said Dr. Harlan Krumholz, MD, SM, Editor-in-Chief of JACC. “This study uniquely isolates ozone’s effects from other pollutants, providing a critical step forward in understanding its independent role in cardiovascular injury.”
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