PCI has no additional benefit over optimal medical therapy in ischemic cardiomyopathy: NEJM
UK: Coronary revascularization with PCI did not provide any additional benefit among patients with severe ischemic left ventricular systolic dysfunction who received optimal medical therapy, a recent study in the New England Journal of Medicine has shown.
The study showed that revascularization by PCI did not result in a lower incidence of hospitalization for heart failure or death from any cause beyond guideline-directed medical therapy (GDMT) in the study population. The findings from the REVIVED-BCIS2 were also presented during a Hot Line session at the European Society of Cardiology (ESC) Congress 2022.
Divaka Perera and colleagues conducted the study in order to determine whether revascularization by the percutaneous coronary intervention (PCI) improves event-free survival and left ventricular function in patients with severe ischemic left ventricular systolic dysfunction versus optimal medical therapy (i.e., individually adjusted pharmacologic and device therapy for heart failure) alone.
The study included 700 patients with a left ventricular ejection fraction of 35% or less, extensive coronary artery disease amenable to PCI, and demonstrable myocardial viability. They were randomly assigned to a strategy of either PCI plus optimal medical therapy (PCI group; n=347) or optimal medical therapy alone (optimal-medical-therapy group; n=353).
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