Seep apnoea tied to heart rate variability and increased cardiovascular load
Longer nocturnal respiratory events in patients with obstructive sleep apnoea (OSA) cause higher immediate heart rate variability, and greater changes in beat-to-beat intervals are associated with reduced daytime alertness, according to new research from the University of Eastern Finland.
Obstructive sleep apnoea affects approximately 1 billion people worldwide. It is one of the most prevalent sleeping disorders, putting a great strain on national economies and on public health. Nocturnal respiratory events, be they complete or partial blocking of the airways, often cause repeated oxygen desaturations and interrupted sleep in patients with OSA, leading to abnormal nervous system function.
Abnormal hyperactivation of the sympathetic nervous system affects heart function and cardiovascular regulation by increasing OSA patients' nocturnal heart rate and by reducing their long-term heart rate variability. These changes have been shown to significantly increase the risk of cardiovascular diseases. In addition, hyperactivation of the sympathetic nervous system can prevent patients with OSA from getting enough deep, restorative sleep, which is why they often feel tired and less alert during the day. Hyperactivation of the sympathetic nervous system can keep the body in a state of alertness over the long term despite sufficient deep sleep, and this can be seen in, e.g., elevated daytime heart rate in patients with OSA.
https://www.nature.com/articles/s41598-020-77780-x
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