Tirzepatide's Effectiveness in HFpEF linked to Baseline BMI and Fat Distribution: SUMMIT Trial
A post hoc analysis of the SUMMIT trial, published in JACC, reveals that baseline body mass index (BMI) and fat distribution significantly affect the response to tirzepatide in patients with heart failure with preserved ejection fraction (HFpEF) and obesity. Patients who lost 15% or more of their body weight experienced greater improvements in exercise capacity, blood pressure, and weight. These findings highlight the importance of baseline BMI in predicting clinical outcomes with tirzepatide therapy. The study was conducted by Barry A. and colleagues.
Obesity is a well-documented cause of HFpEF, an entity of heart failure in which cardiac pumping function is maintained but relaxation and filling are impaired. Conventional treatment has been in this subset of patients. Tirzepatide, a weekly injectable medication, engages both the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors and is effective in weight reduction and metabolic regulation. The SUMMIT trial tested its impact in 731 obese (BMI ≥30 kg/m²) and HFpEF patients categorized under NYHA class II-IV. The patients were randomized to tirzepatide (n=364) or placebo (n=367) for 52 weeks.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.