Use of SGLT-2 inhibitors for HF management safe and well tolerated in adult congenital heart disease patients: Study

For this purpose, they performed a retrospective, single-centre analysis of 18 patients (>18 years of age) with ACHD and an HF diagnosis who were initiated on an SGLT2 inhibitor. Patient characteristics, including vital signs, concomitant medications, laboratory values, echocardiograms, and clinical outcomes, were obtained as a part of standardized clinical care at an ACHD program before and 2–6 months after initiation of SGLT-2i.

The primary outcome was to demonstrate the safety of SGLT-2i initiation via potential changes in systolic blood pressure, serum creatinine, and serum sodium.

The study revealed the following findings:

• Of the 18 patients, 11 had moderate complexity congenital heart disease, while 7 had great complexity congenital heart disease.
• Post initiation, there were no significant differences in systolic blood pressure (121.8 ± 20.8 mmHg to 114.4 ± 14.9 mmHg), creatinine level (0.85 ± 0.18 mg/dL to 0.89 ± 0.18 mg/dL), and sodium level (138.7 ± 2.9 mMol/L to 138.0 ± 2.2 mMol/L).
• There was a statistically significant weight decline (78.9 ± 22.9 kg to 76.0 ± 23.0 kg) but without a statistically significant change in NT-pro NBP (1358.2 ± 2735.0 pg/mL to 601.6 ± 786.1 pg/mL).

The researchers report that the use of SGLT-2i in their small cohort of patients with heterogenous ACHD appears safe and well tolerated.

"The safety and potential efficacy of SGLT-2i in patients with adult congenital heart disease will require further evaluation in large-scale prospective multicenter studies," they concluded.

Reference:

Kheiwa, A., Ssembajjwe, B., Chatta, P., Nageotte, S., & Abramov, D. (2024). Safety of SGLT-2 inhibitors in the management of heart failure in the adult congenital heart disease patient population. International Journal of Cardiology Congenital Heart Disease, 100495. https://doi.org/10.1016/j.ijcchd.2024.100495