2020 in a nutshell: The hottest developments in the field of cardiology this year. Section 1. General and preventive cardiology
4. EVAPORATE (Effect of Icosapent Ethyl on Progression of Coronary Atherosclerosis in Patients With Elevated Triglycerides on Statin Therapy) trial
Icosapent ethyl 4 g/day reduces low attenuation plaque volume at 18 months compared with placebo among patients with known CAD, as assessed by cardiac CT angiography (CTA)
Eligible patients were randomized in a 1:1 fashion to either icosapent ethyl 4 g/day (n = 40) or placebo.
The results of this trial indicate that icosapent ethyl 4 g/day reduces low attenuation plaque volume compared with placebo at 18 months, as measured by cardiac CTA. In addition, there was a reduction in total plaque volume and other plaque parameters as well. In the setting of a small sample size, there was no difference in triglyceride levels. These results may help explain the cardiovascular benefit noted with icosapent ethyl in the REDUCE-IT trial. Source: European Heart Journal: Budoff MJ, Bhatt DL, Kinninger A, et al. Effect of icosapent ethyl on progression of coronary atherosclerosis in patients with elevated triglycerides on statin therapy: final results of the EVAPORATE trial. Eur Heart J 2020;Aug 29
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