CARDIOLOGY UPDATE-ABSORB III TRIAL- 2015
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CARDIOLOGY UPDATES
ABSORB III TRIAL-
Everolimus-eluting bioresorbable scaffolds for CAD proven to be only non-inferior to Xience stent.
The fully bioresorbable Absorb vascular scaffold elutes everolimus and was developed to improve long-term outcomes after stent implantation. In previous trials and registries, the Absorb bioresorbable vascular scaffold (BVS; Abbott Vascular) has been found to be similar to the Xience cobalt-chromium everolimus-eluting stent in terms of the rates of adverse events at 1 year after implantation, but these studies were underpowered for clinical endpoints. ABSORB III was a large-scale, multicenter trial to determine the relative safety and effectiveness of the Absorb BVS compared to the Xience stent in patients with coronary artery disease.
A total of 2008 patients with stable or unstable angina were randomly assigned in a 2:1 ratio to receive an Absorb BVS or a Xience stent.
The primary endpoint of target-lesion failure (TVF; cardiac death, target-vessel MI, or ischemia-driven target lesion revascularization) at 1 year occurred in 7.8% of patients in the Absorb group and in 6.1% of patients in the Xience group (difference, 1.7%; p=0.007 for non-inferiority and 0.16 for superiority).
ABSORB III TRIAL-
Everolimus-eluting bioresorbable scaffolds for CAD proven to be only non-inferior to Xience stent.
The fully bioresorbable Absorb vascular scaffold elutes everolimus and was developed to improve long-term outcomes after stent implantation. In previous trials and registries, the Absorb bioresorbable vascular scaffold (BVS; Abbott Vascular) has been found to be similar to the Xience cobalt-chromium everolimus-eluting stent in terms of the rates of adverse events at 1 year after implantation, but these studies were underpowered for clinical endpoints. ABSORB III was a large-scale, multicenter trial to determine the relative safety and effectiveness of the Absorb BVS compared to the Xience stent in patients with coronary artery disease.
A total of 2008 patients with stable or unstable angina were randomly assigned in a 2:1 ratio to receive an Absorb BVS or a Xience stent.
The primary endpoint of target-lesion failure (TVF; cardiac death, target-vessel MI, or ischemia-driven target lesion revascularization) at 1 year occurred in 7.8% of patients in the Absorb group and in 6.1% of patients in the Xience group (difference, 1.7%; p=0.007 for non-inferiority and 0.16 for superiority).
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