Eosinophil Levels may predict prognosis in critically ill patients with HFrEF: Study

Among these patients, in-hospital mortality was 14.5% (389 patients), and the overall 90-day mortality rate reached 27.12% (726 patients). There were no significant differences in EOS levels between the HFrEF and HFpEF groups (0.1 vs. 0.09, P = 0.154). After adjusting for confounders, multivariate logistic regression showed that higher EOS quartiles were associated with reduced in-hospital mortality in HFrEF patients, with quartile 3 (Q3) (OR 0.54, 95% CI 0.31-0.96, P = 0.035) and Q4 (OR 0.37, 95% CI 0.19-0.71, P = 0.003) showing significant protective effects compared with the lowest EOS quartile (Q1), while Q2 did not reach statistical significance (P = 0.931). Subgroup analyses yielded similar findings.

Multivariate Cox regression demonstrated a reduced hazard ratio in Q4 (HR 0.64, 95% CI 0.44-0.94, P = 0.023) compared with Q1 in HFrEF patients. However, no significant association was observed between EOS and prognosis in HFpEF. The findings indicated that higher EOS was associated with improved in-hospital and 90-day survival in ICU patients with HFrEF, but not in those with HFpEF.

Reference:

Guan C, Wang K, Gong A, Zhao Y, Yu H, Zhang S, Jin S, Wang L, Xiao B. Association between blood eosinophil levels and prognosis in critically ill patients with different heart failure phenotypes. Sci Rep. 2025 Feb 19;15(1):6008. doi: 10.1038/s41598-025-90778-7. PMID: 39972112; PMCID: PMC11840013.