Frailty Index ranks over SOFA in predicting 3-month mortality in Sepsis

New research published in the Journal of the Association of Physicians of India found that the frailty index was superior to sequential organ failure assessment (SOFA) and the other prognostic markers of sepsis in predicting the 3-month mortality rate. Frailty index showed greater sensitivity and negative predictive value while SOFA had higher specificity in predicting in-hospital mortality.
Traditional prognostic markers and scores in critical illness rely excessively on derangements in acute physiologic state at or within 24 hours of admission. But they do not include sociodemographic characteristics. As elders have unique physiology and have a widely varying response to sepsis, researchers from All India Institute of Medical Sciences, India conducted a study to assess the potential of frailty index as a prognostic marker of sepsis in the elderly in comparison with traditional markers such as SOFA, systemic inflammatory response syndrome (SIRS), and quick sequential organ failure assessment (qSOFA).
A prospective cohort study was conducted in a tertiary level hospital in North India from January 2020 to July 2021. Within 24 hours of admission in elderly patients suspected to have sepsis, the frailty index was calculated along with traditional markers. The area under the receiver operating characteristic (AUROC) of frailty index, SOFA, qSOFA, and SIRS was compared for in-hospital and 3-month mortality.
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