High degree of platelet reduction associated with mortality in Sepsis, finds study
Sepsis is a potentially life-threatening condition arising from tissue and organ damage due to a body's overactive response to an infection. It is commonly characterized by abnormally low levels of platelet, considered to be associated with its high mortality rate.
Researchers at Nagoya University researchers have demonstrated that a high degree of platelet reduction, rather than an abnormally low platelet count, raises mortality risks in sepsis. The findings could lead to the development of precise and preventive treatments for sepsis-associated coagulopathy.
The new research has appeared in the journal Scientific Reports.
It is known that during sepsis, a serious blood disorder called disseminated intravascular coagulation (DIC) forms tiny blood clots throughout the bloodstream, resulting in platelet depletion. From this perspective, absolute platelet count has been used as the international criterion for the diagnosis of sepsis-associated DIC and has led researchers to conduct clinical trials based on this criterion. However, very few of these trials have led to the development of effective treatments for sepsis-associated DIC, and currently, there is no breakthrough therapy.
https://www.nature.com/articles/s41598-021-93635-5
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