High serum caspase-8 concentration predicts death risk in spontaneous intracerebral haemorrhage
Spain: A recent study in the journal Anaesthesia Critical Care & Pain Medicine has revealed an associaiton between high serum caspase-8 concentrations and mortality in spontaneous intracerebral haemorrhage (SIH). This implies that serum caspase-8 levels could be utilized as prognostic biomarker mortality.
"Results showed that non-surviving at 30 days had higher serum caspase-8 levels than surviving patients, " Leonardo Lorente, Intensive Care Unit, Hospital Universitario de Canarias, Ofra s/n, La Laguna, Santa Cruz de Tenerife, Spain, and colleagues wrote in their study.
Apoptotic changes in brain samples have been seen in haematoma areas of SIH patients undergoing surgical haematoma evacuation. However, there is no description of circulating caspase-8 concentrations in SIH patients. Considering this, Dr. Lorente and the team aimed to explore an association of circulating caspase-8 concentrations and mortality in SIH patients in a observational and prospective study.
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