High serum caspase-8 concentration predicts death risk in spontaneous intracerebral haemorrhage

Salient findings of the study include:

• Surviving (n = 41) in respect to non-surviving SIH patients (n = 38) showed lower serum caspase-8 levels.
• The area under the curve to estimate 30-day mortality ability by serum caspase-8 levels was 0.75.
• Kaplan-Meier analysis found that patients with serum caspase-8 levels > 17.8 ng/mL showed higher death risk (Hazard ratio = 3.9).
• Multiple logistic regression analysis revealed the association of serum caspase-8 concentrations (controlling for intracerebral haemorrhage score, midline shift and early haematoma evacuation) with mortality at 30 days (Odds Ratio = 1.048).

"The main of novel findings that have been revealed in our study is the association of serum caspase-8 concentrations with mortality of SIH patient mortality," wrote the authors.

Reference:

The study titled, "Mortality of spontaneous intracerebral haemorrhage patients and high serum caspase-8 concentrations," was published in the journal Anaesthesia Critical Care & Pain Medicine. 

DOI: https://doi.org/10.1016/j.accpm.2021.100969