Post-traumatic stress disorder trajectories in sepsis survivors

Recently published study identified and predict trajectories of post-traumatic stress symptoms in sepsis survivors up to two years after discharge from the ICU. It addressed the limited research on long-term trajectories of post-traumatic stress and potentially modifiable risk factors following the ICU stay. The study included data on post-traumatic stress symptoms collected from sepsis survivors at one, six, 12, and 24 months after ICU discharge. The results identified three distinct trajectories of post-traumatic stress symptoms: stable low symptoms (59% of patients), increasing symptoms (26%), and recovering from symptoms (15%). Patients with initially high post-traumatic symptoms were more likely to show a decrease. Females and patients reporting early traumatic memories of the ICU were at higher risk for increasing post-traumatic stress symptoms.

Implications of Findings

The findings suggest that post-traumatic stress is a relevant long-term burden for sepsis patients after ICU stay and highlight the importance of regular screening for post-traumatic stress, especially in patients with few initial symptoms. The study suggests the need for timely screening for early traumatic memories after ICU discharge and regular monitoring of post-traumatic stress symptoms in the long term. Additionally, it indicates that women may be at a higher risk of increasing symptom severity and emphasizes the importance of screening and monitoring, particularly in general practice settings.

Limitations and Recommendations

The study provides valuable insights into the long-term trajectories of post-traumatic stress symptoms in sepsis survivors and identifies potential risk factors for adverse mental health outcomes. However, it also acknowledges certain limitations, such as the exploratory nature of the analysis and the need for replication in larger prospective cohorts with more measurement points. Overall, the study contributes to the understanding of post-traumatic stress in ICU survivors and emphasizes the need for ongoing monitoring and support for sepsis survivors.

Reference –

Schmidt, K.F.R., Gensichen, J.S., Schroevers, M. et al. Trajectories of post-traumatic stress in sepsis survivors two years after ICU discharge: a secondary analysis of a randomized controlled trial. Crit Care 28, 35 (2024). https://doi.org/10.1186/s13054-024-04815-4.