PTX3 levels act as biomarkers of mortality in patients with sepsis: BMC
China: In a new study conducted by Guobin Wang and the team, it was found that individuals with sepsis who did not survive had much greater levels of Pentraxin-3 (PTX3) than patients who did. Mortality was significantly correlated with elevated PTX3 levels. The findings of this study were published in BMC Critical Care Journal.
Acute-phase protein PTX3 is a member of the long-chain pentameric protein superfamily. It plays a significant part in the control of inflammation as a vital part of the human innate immune system. The literature has demonstrated that an increased risk of patient mortality from sepsis was linked to a higher level of PTX3. Therefore, this study was conducted to define the predictive significance of Pentraxin-3 (PTX3) on the mortality of sepsis patients.
PubMed, EMBASE, and the Cochrane library were searched for publications that had been published as recently as January 2021. For the meta-analysis, information was taken from case-control and cohort studies that were eligible. To assess the relationship between results and sample size and the percentage of men, multivariate regression analysis was utilized.
The key findings of this study were as follows:
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