Tryptase has limited sensitivity as Anaphylaxis Biomarker, claims study
Written By : Dr. Shravani Dali
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2025-04-29 03:30 GMT | Update On 2025-04-29 06:35 GMT
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Tryptase is the most commonly used biomarker for diagnosing anaphylaxis; however, it has limited sensitivity. A recent systematic review found its sensitivity to be only 49%, raising concerns about potential misclassification of anaphylaxis cases despite its status as the most reliable current marker.
Anaphylaxis is a life-threatening allergic reaction commonly triggered by food, venom, or drugs. Clinical criteria are central to diagnosing anaphylaxis. However, laboratory biomarkers could provide valuable confirmation when clinical diagnosis is challenging.
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