Tryptase has limited sensitivity as Anaphylaxis Biomarker, claims study
Tryptase is the most commonly used biomarker for diagnosing anaphylaxis; however, it has limited sensitivity. A recent systematic review found its sensitivity to be only 49%, raising concerns about potential misclassification of anaphylaxis cases despite its status as the most reliable current marker.
Anaphylaxis is a life-threatening allergic reaction commonly triggered by food, venom, or drugs. Clinical criteria are central to diagnosing anaphylaxis. However, laboratory biomarkers could provide valuable confirmation when clinical diagnosis is challenging.
They aimed to evaluate key biomarkers including tryptase, histamine, platelet-activating factor (PAF), PAF-acetylhydrolase (PAF-AH), and urinary prostaglandin D2 (PGD2) for their diagnostic utility in anaphylaxis. A systematic review was conducted following PRISMA-DTA guidelines. Studies published between 2004 and 2024 from Embase and MedLine were included if they evaluated the diagnostic test accuracy of tryptase, histamine, PAF, PAF-AH, or urinary PGD2 in confirmed anaphylaxis cases. Pooled sensitivity and specificity estimates were calculated using the diagmeta package in R.
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