Add on Calcium Cyclotriphosphate to Hydrogen Peroxide Bleaching Gels May Minimize Enamel Damage: Study Finds

The study led to the following findings:

• All bleaching gels induced significant color changes after treatment, with comparable ΔE, ΔE00, and ΔWID values across groups.
• Mineral loss (SH, gHAp × cm⁻³ × µm), surface roughness (Ra), and HP diffusion were highest with the 35% HP gel and lowest in groups containing CaNaTMP, particularly at 1%.
• SEM/EDX analysis showed no visible surface alterations in the 17.5% HP group, while the 1% CaNaTMP-containing group exhibited prominent amorphous apatite precipitation.
• Adding CaNaTMP, especially at 0.5% and 1%, to the 35% HP gel minimized surface changes.

The researchers demonstrated that incorporating CaNaTMP into 17.5% and 35% HP bleaching gels effectively reduced mineral loss, surface roughness, and enamel morphology alterations while limiting trans-amelodentinal diffusion of H₂O₂, without affecting bleaching efficacy. The protective effects were more pronounced with 1% CaNaTMP, particularly in preserving enamel integrity.

"By enhancing the safety and biocompatibility of bleaching gels, this approach offers a promising strategy for minimizing enamel damage. The combination of 17.5% HP with 1% CaNaTMP emerged as a safer and effective whitening option, improving patient comfort during treatment," the researchers concluded.

Reference:

Nunes, G. P., Batista, G. D. F., De Toledo, P. T. A., Martins, T. P., Alves, R. D. O., Fernandes, A. V. P., & Delbem, A. C. B. (2025). Synthesis and application of calcium cyclotriphosphate in bleaching formulations: Effects on dental enamel properties. Journal of Dentistry, 155, 105614. https://doi.org/10.1016/j.jdent.2025.105614