Antidepressant Use Linked to Reduced Prevalence of Periodontitis: Findings from Large-Scale U.S. Sample

The authors proposed several possible explanations for this association. One is that individuals receiving treatment for depression may be more likely to engage in regular medical and dental care, leading to earlier detection and management of oral health issues. Another explanation is that antidepressants may influence biological pathways related to inflammation and immune function, thereby reducing the severity of gum tissue damage. While antidepressants are known to cause dry mouth in some patients, the overall findings indicate that their therapeutic effects on mood and systemic inflammation could outweigh potential oral side effects when it comes to periodontal outcomes.

The study underscores the growing recognition of the connection between mental health and oral health. It suggests that integrated healthcare approaches that consider both psychological and dental well-being could improve overall patient outcomes. Dentists and physicians are encouraged to collaborate in managing patients with depression, ensuring that those on antidepressants receive appropriate oral care guidance. These findings open the door for further research into how mental health treatments can positively influence oral and systemic health.

Reference (APA Style): Martínez, A., et al. (2025). *Reduced prevalence of periodontitis in antidepressant users: Findings from a large-scale US sample. Journal of Periodontology. Wiley Online Library. [https://onlinelibrary.wiley.com/doi/10.1002/JPER.XXXX](https://onlinelibrary.wiley.com/doi/10.1002/JPER.XXXX)