Genetic single-nucleotide polymorphisms variants may be developed as screening tools for dental caries in future

A representative sample of all 5,914 births from the 1982 Pelotas birth cohort study was prospectively investigated. Dental caries trajectory across the life course was assessed at 15(n = 888), 24(n = 720), and 31 years old(n = 539). Group-based trajectory modeling was used to identify distinct subgroups of individuals whose caries measurements followed a similar pattern over time. Genetic material was collected, and individuals were genotyped [rs4970957(TUFT1), rs1711437(MMP20), rs1784418(MMP20), rs2252070(MMP13), rs243847(MMP2), rs2303466(DLX3), rs11656951(DLX3), rs7501477(TIMP2), rs388286(BMP7), and rs5997096(TFIP11)]. Analyzes were performed for allele and genotype using logistic regression and generalized multifactor dimensionality reduction for epistatic interactions.

Results

The analyses included 678 individuals, those with allele C, genotype CC in the additive effect, and the genotype TC/CC in dominant effect on the rs243847(MMP2) were associated with low caries trajectory.

Individuals with the allele T and the genotype TC/CC in dominant effect on the rs5997096(TFIP11) were associated with low caries trajectory. Positive epistatic interactions were observed involving two and three loci and high caries trajectory.

Some SNPs present in the genes of tooth mineral tissues were associated with caries trajectory and epistatic interactions increasing the network of SNPs involved in individual caries experience. Single nucleotide polymorphisms in the pathway of tooth mineral tissues genes may contribute significantly to the individual caries experience across the life course.

Reference:

Luiz Alexandre Chisini, Francine da costa Santos, Rodrigo Varella de Carvalho, Bernardo Lessa Horta, Luciana Tovo-Rodrigues, Flávio Fernando Demarco, Marcos Britto Correa,

Impact of tooth mineral tissues genes on dental caries: A birth-cohort study,

Journal of Dentistry, Volume 133, 2023, 104505, ISSN 0300-5712. https://doi.org/10.1016/j.jdent.2023.104505.

(https://www.sciencedirect.com/science/article/pii/S030057122300091X)

Keywords:

Genetic, single-nucleotide, polymorphisms, variants, developed, screening tools, dental caries, future, Luiz Alexandre Chisini, Francine da costa Santos, Rodrigo Varella de Carvalho, Bernardo Lessa Horta, Luciana Tovo-Rodrigues, Flávio Fernando Demarco, Marcos Britto Correa, Journal of Dentistry