NeoMTA Plus, ProRoot MTA and Biodentine useful as reparative biomaterials: Study

Medically Reviewed By : Dr. Kamal Kant Kohli

Published On 2021-11-16 03:30 GMT | Update On 2021-11-16 03:30 GMT

Researchers from a recent study have observed that NeoMTA Plus, ProRoot MTA and Biodentine materials extracts are not cytotoxic and do not induce apoptosis in the human dental pulp stem cells (hDPSCs).

The study is published in the Journal of Dental Sciences.

Dental pulp stem cells (DPSCs) play a crucial role in the tissue healing process through odontoblast like cell differentiation.

Calcium silicate cements, such as Mineral trioxide aggregate (MTA) and Biodentine, have a wide and successful range of various clinical dental applications. Tricalcium silicate cements are called dental biomaterials because of their physicochemical and biocompatibility.

NeoMTA Plus was developed with similar properties to MTA. It is stated that NeoMTA Plus does not cause discoloration in dental tissues, it has sufficient radiopacity and hydration with MTA and it shows the production of calcium hydroxide required to induce mineralized tissue formation.

Hence, Sinem Birant and associates from the Istanbul University-Cerrahpasa, Faculty of Dentistry, Department of Pedodontics, Istanbul Turkey conducted the present study to evaluate the biocompatibility and compare the potential invitro cytotoxic effects of NeoMTA Plus, ProRootMTA and Biodentine on human dental pulp stem cells (hDPSCs).

To assess the effects of NeoMTA Plus, ProRoot MTA and Biodentine extracts at 1st, 3rd and 7th d on hDPCs, cell populations was determined by flow cytometry using an Annexin V detection kit. The data were analyzed statistically using the Kruskal–Wallis test. A p < 0.05 was considered as statistically significant.

The results showed that all groups showed cell viability similar to that of the control group on 1st, 3rd and 7th d. Although Biodentine exhibited higher cell viability rates than the other material groups, no statistically significant differences were noted between the sampled days (p > 0.05).

Therefore, the authors concluded that "all materials extracts are not cytotoxic and do not induce apoptosis in the hDPSCs. These results suggest that all the tested materials can lead to positive outcomes when used as reparative biomaterials."

Article Source : Journal of Dental Sciences

Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.

NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.

Dr. Nandita Mohan

Dr. Nandita Mohan is a practicing pediatric dentist with more than 5 years of clinical work experience. Along with this, she is equally interested in keeping herself up to date about the latest developments in the field of medicine and dentistry which is the driving force for her to be in association with Medical Dialogues. She also has her name attached with many publications; both national and international. She has pursued her BDS from Rajiv Gandhi University of Health Sciences, Bangalore and later went to enter her dream specialty (MDS) in the Department of Pedodontics and Preventive Dentistry from Pt. B.D. Sharma University of Health Sciences. Through all the years of experience, her core interest in learning something new has never stopped. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751

Comments Policy

Our comments section is governed by our Comments Policy . By posting comments at Medical Dialogues you automatically agree with our Comments Policy , Terms And Conditions and Privacy Policy .

NeoMTA Plus, ProRoot MTA and Biodentine useful as reparative biomaterials: Study

Similar News

Hemolaser Therapy Effectively Reduces Interdental Black Spaces and Improves Patient Comfort: Study

Flapless Immediate Implants with Bone Graft May Aid Bone Preservation, reveals research

Udaipur's Dental College BDS student commits suicide, alleges mental harassment in note, 2 accused faculty expelled

Hard evidence of soft teeth: the oral symptoms of hypophosphatasia

Delayed-Onset Peritonitis After Root Canal in PD Patient: Doctors Report First Case

Direct pulp capping or partial pulpotomy effective treatment of Carious Pulp Exposure in Reversible Pulpitis: Study

Higher Dental Radiation Doses Tied to Increased Risk of Cavities in Head and Neck Cancer Patients: Study Finds

Poor Oral Health Significantly Linked to Pre-Eclampsia in Pregnancy: Study