SARS-CoV-2 infection tied with oral and maxillofacial mycoses: study

Written By :  Dr. Shravani Dali
Medically Reviewed By :  Dr. Kamal Kant Kohli
Published On 2022-03-08 03:30 GMT   |   Update On 2022-03-08 03:30 GMT
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SARS-CoV-2 infection is tied with oral and maxillofacial mycoses, according to a recent study published in the International Dental Journal.

Studies reviewing oro-facial mycoses in Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) infection are sparse. Here we review the major oral and maxillofacial mycoses of COVID-19, the associated comorbidities, and the probable precipitating factors.

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English language manuscripts published between March 2020 and October 2021 were searched using PubMed, OVID, SCOPUS, and Web of Science databases, using appropriate keywords.

Results:

They identified 30 articles across 14 countries, which met the inclusion criteria of PRISMA guidelines. These yielded a total of 292 laboratory-confirmed COVID-19 patients, 51.4% (n=150) of whom presented with oral and maxillofacial fungal infections, mainly comprising candidosis, mucormycosis, and aspergillosis. Candidal infections were the most prevalent, present in 64% (n = 96), followed by mucormycosis, and only a single case of aspergillosis was noted. Oral and maxillofacial mycoses were predominantly seen in those with comorbidities, especially in diabetics (52.4%). Oral mucormycosis was noted in 8.6% (n=13) and mainly manifested on the hard palate. An overall event rate of oral/maxillofacial mucormycosis manifestation in COVID-19 patients with diabetes mellitus Type 1/2 was around 94% (49/52; 95% CI: 0.73%-0.89%), implying a very high association between diabetes mellitus and the latter condition. All fungal infections appeared either concurrently with COVID-19 symptoms or during the immediate recovery period.

Thus, the researchers concluded that SARS-CoV-2 infection-related immunosuppression, steroid therapy, as well as co-morbidities such as diabetic hyperglycemia appear to be the major predisposing factors for the onset of oral and maxillofacial mycoses in COVID-19 patients across all age groups.

Reference:

Oro-facial Mycoses in Coronavirus Disease-2019 (COVID-19): A Systematic Review by LP Samaranayake et al. published in the International Dental Journal.

https://www.sciencedirect.com/science/article/pii/S0020653922000351?v=s5

Keywords: Oro-facial Mycoses, Oro-facial Mycoses in Covid-19, Oro-facial Mycoses and covid-19, impact of Oro-facial Mycoses, covid-19 oral complication, covid-19 fungal complication, black fungus disease, International Dental Journal, LP Samaranayake, KS Fakhruddin H, CN Bandara,Y Leung, COVID-19, systematic review, candidiasis, aspergillosis, Mucormycosis


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Article Source : International Dental Journal

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