Single antibiotic paste as good as combined antibiotic therapy for root canal disinfection
Single antibiotic paste has considerably higher or similar antibacterial effectiveness compared to double antibiotic paste, calcium hydroxide, and triple antibiotic paste according to a recent study published in the Journal of Conservative Dentistry. Further combination of antibiotics (as in DAP, mTAP, or TAP) seems not to be a necessity for root canal disinfection.
Conflicting findings on the potency of antibiotic pastes versus calcium hydroxide (CH) have been evident in the literature. Aims: To compare the antibacterial efficacy of single antibiotic paste (SAP), double antibiotic paste (DAP), triple antibiotic paste (TAP), and modified TAP (mTAP) with CH on bacterial biofilms.
PubMed, Scopus, and Embase were comprehensively searched until August 23, 2021. The study protocol was registered in the PROSPERO. Ex vivo studies performed on Enterococcus faecalis or polymicrobial biofilms incubated on human/bovine dentin were selected. The quality of the studies was assessed using a customized quality assessment tool. Standardized mean difference (SMD) with a 95% confidence interval (CI) was calculated for the meta-analysis. Meta-regression models were used to identify the sources of heterogeneity and to compare the efficacy of pastes.
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