Specific salivary biomarker combinations useful screening tools for periodontitis

Results

Twenty-one combinations in GCF and 47 in saliva were evaluated. Meta-analyses were possible for six salivary combinations (median sensitivity/specificity values): IL-6 with MMP-8 (86.2%/80.5%); IL-1β with IL-6 (83.0%/83.7%); IL-1β with MMP-8 (82.7%/80.8%); MIP-1α with MMP-8 (71.0%/75.6%); IL-1β, IL-6 and MMP-8 (81.8%/84.3%); and IL-1β, IL-6, MIP-1α and MMP-8 (76.6%/79.7%).

Two-biomarker combinations in oral fluids show high diagnostic accuracy for periodontitis, which is not substantially improved by incorporating more biomarkers. In saliva, the dual combinations of IL-1β, IL-6 and MMP-8 have an excellent ability to detect periodontitis and a good capacity to detect non-periodontitis. Because of the limited number of biomarker combinations evaluated, further research is required to corroborate these observations.

Refernence:

Blanco-Pintos, T., Regueira-Iglesias, A., Seijo-Porto, I., Balsa-Castro, C., Castelo-Baz, P., Nibali, L., & Tomás, I. (2023). Accuracy of periodontitis diagnosis obtained using multiple molecular biomarkers in oral fluids: A systematic review and meta-analysis. Journal of Clinical Periodontology, 1–24.  https://doi.org/10.1111/jcpe.13854

Keywords:

Specific, salivary, biomarker, combinations, screening tools, periodontitis, Blanco-Pintos, T., Regueira-Iglesias, A., Seijo-Porto, I., Balsa-Castro, C., Castelo-Baz, P., Nibali, L., & Tomás, I, Journal of Clinical Periodontology