Stem cells may have potential role in regeneration of immature permanent teeth: Study

Results:

• A new protocol of treating endodontically involved immature permanent teeth based on published articles to date is summarized in the review.
• The key procedures of the protocol are (1) minimal or no instrumentation of the canal while relying on a gentle but thorough irrigation of the canal system, (2) the disinfection is augmented with intra-canal medication of a triple-antibiotic paste between appointments, and (3) the treated tooth is sealed with mineral trioxide aggregate (MTA) and glass ionomer/resin cement at the completion of the treatment.
• Periodical follow-ups will take place to observe any continued maturation of the root.

While more clinical research is needed, regenerative endodontics promotes a paradigm shift in treating endodontically involved immature permanent teeth from performing apexification procedures to conserving any dental stem cells that might remain in the disinfected viable tissues to allow tissue regeneration and repair to achieve apexogenesis/maturogenesis.

Reference:

A paradigm shift in endodontic management of immature teeth: conservation of stem cells for regeneration by George T.-J.Huang et al. published in the Journal of Dentistry

https://doi.org/10.1016/j.jdent.2008.03.002