Sucralfate mouthwash useful and safe management option of cancer therapy-induced OM: Study

The risk of bias was assessed, and a network meta-analysis was conducted. Results: Of 2913 results, 30 randomized clinical trials were considered suitable for inclusion. A total of 2564 patients were analyzed, of which 1284 belonged to the test group and 1280 belonged to the control group. Natural products were the most used, followed mainly by antimicrobial agents, coating agents, and basic oral care measures. Topical sucralfate resulted in the most powerful intervention for the OM prevention (OR = 0.04, 95%C.I. = 0.01–0.25, p-value = 0.001). Due to its cytoprotective action, low cost, ease of administration, and safety, sucralfate could become a potential ally to prevent the onset of OM during cancer therapy.

Coppini, M., Caponio, V. C. A., Mauceri, R., Bizzoca, M. E., Laino, L., Lorenzo-Pouso, A. I., Russo, D., Troiano, G., Silva, F. F. V. E., Lo Muzio, L., & Campisi, G. (2024). Efficacy of topical agents in oral mucositis prevention: Systematic review and network meta-analysis. Oral Diseases, 00, 1–19. https://doi.org/10.1111/odi.15046