Sweet taste receptor gene linked to caries risk
A 2023 study published in the Journal Of Dental Research has established the connection between the genes related to taste receptors and dental caries in the early dentition period involving age groups of 15 years, 24 years, and 31 years in the Oral Health Survey conducted by the panel of dentists. The oral examination was done clinically with the use of a mouth mirror & probe based on the criteria of Decayed, Missing, and Filled Teeth (DMFT) index.
According to the current research, sweet taste has been associated with a specific G protein- mainly expressed in epithelial cells of the tongue & palate- with the gene expressions T1R1, T1R2, and T1R3; T represents taste and R for receptors of three different types. Sweet taste receptors with genotype TAS1R3 (rs307355) and T1S1R2(rs35874116) were found to be valuable assets for further study. T1R2 and T1R3 are the core receptors for sweet taste in humans. Previous findings from Luciferase Reporter Assay have affirmed the effect of rs307355(TAS1R3) in gene transcription via altering the function and influencing the ability of the sweet taste in individuals belonging to different regions.
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