White Spot Lesions may Show Higher hydrogen peroxide Permeability and Poorer Whitening Results: Study

The results confirmed that WSLs significantly increased HP diffusion with in-office bleaching (p < .05), indicating heightened sensitivity risk. Moreover, the optical outcomes were consistently poorer: WSL-teeth showed lower lightness (L*) and whitening index (WI_D) values compared to sound teeth across treatments. Notably, differences remained regardless of bleaching method, although at-home bleaching avoided excessive HP penetration and produced marginally better esthetic results.

These findings raise concern about the safety and effectiveness of aggressive bleaching in teeth with WSLs, which are already structurally compromised. The authors propose that gentler, home-based bleaching protocols combined with remineralization strategies may preserve enamel integrity while improving appearance safely. For clinicians, this means evaluating lesion type before choosing a bleaching method and advising conservative options when WSLs are present. Further clinical trials are needed to verify long-term outcomes and guide tailored bleaching protocols for patients with enamel hypomineralization.