Researchers report a case of porphyria cutanea tarda associated with hepatitis C
Memphis, TN: A recent case study published in the New England Journal of Medicine (NEJM) describes a rare case of porphyria cutaneous yards associated with Hepatitis C.
The case is reported by Dr. Tejesh S. Patel and Dr. Evgeniya Teterina Mohammed from the University of Tennessee Health Science Center, Memphis, Tennessee.
Porphyria cutanea tarda (PCT) is the most common type of porphyrias. Usually, the disease manifests with dermatological signs, including skin fragility and vesciculo-bullous eruption on the hand and face, which become evident after exposure to sunlight.
The case in question is of a 65-year-old man who was presented to the dermatology clinic with a 6-month history of worsening lesions on his hands and forearms as well as fingernail thickening.
His medical history included end-stage renal disease and untreated hepatitis C virus infection. Physical examination showed crusted erosions and atrophic scars on the dorsal hands and forearms as well as scattered tense vesicles on the fingers and forearms. Onychodystrophy and subungual hyperkeratosis were observed in the fingernails. A 24-hour urine sample showed an elevated level of uroporphyrins (558 μg [672 nmol]; normal range, 0 to 24 μg [0 to 28 nmol]).
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