50% of CAPS patients present with cutaneous involvements, including distal inflammatory edema: JAMA
A new study found that in patients with Catastrophic antiphospholipid syndrome (CAPS), nearly half of them presented with cutaneous involvement having a wide spectrum of clinical presentations like distal inflammatory edema. The study results were published in the journal JAMA Dermatology.
Antiphospholipid syndrome (APS) presents with a rare, severe complication called Catastrophic antiphospholipid syndrome (CAPS) characterized by diffuse small-vessel thromboses leading to multiorgan failure. Despite several clinical presentations, cutaneous involvement has not been thoroughly described. Hence researchers conducted a study to describe the cutaneous involvement, its clinical and pathological features, and outcomes in these patients and to compare them without cutaneous involvement.
A retrospective cohort study was conducted by including patients from the French multicenter APS/systemic lupus erythematosus register (ClinicalTrials.gov: NCT02782039) by December 2020. All patients meeting the revised international classification criteria for CAPS were included, and patients with cutaneous manifestations were analyzed more specifically. Patients with CAPS having cutaneous involvement, clinical and pathological data, as well as course and outcome, were gathered from patients and compared to those in the register who did not have cutaneous involvement.
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