Add on phototherapy to ritlecitinib Boosts Vitiligo Treatment Response and Patient Satisfaction: Study
Researchers have found in an exploratory phase IIb study that adding twice-weekly narrowband UVB phototherapy to oral ritlecitinib (Litfulo) improved repigmentation outcomes in patients with nonsegmental vitiligo compared to ritlecitinib alone. The combination therapy was well-tolerated with no new safety concerns, and patient satisfaction nearly doubled with the dual approach.
Ritlecitinib, an oral selective dual JAK3/TEC family kinase inhibitor, was evaluated for its efficacy and safety in adolescents and adults with alopecia areata in a large, randomized, double-blind, multicentre phase 2b–3 clinical trial. Conducted across 118 sites in 18 countries, the study included patients aged 12 years and older with at least 50% scalp hair loss. Participants were randomly assigned to various dosing regimens of ritlecitinib or placebo over a 24-week treatment period, followed by a 24-week extension during which those initially on placebo were switched to ritlecitinib.
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