Alopecia Patients on Low-Dose Minoxidil not at Increased Risk of Pericardial Effusion, suggests study

Against the above background, Colin M. Kincaid MDa, Department of Dermatology, University of California, Irvine, CAbDivision of Cardiology, University of California, Irvine, CA, and colleagues aimed to examine if low-dose oral minoxidil is linked to a higher prevalence of pericardial effusions in patients with alopecia.

For this purpose, the researchers employed point-of-care ultrasound to screen alopecia patients during dermatology appointments in the cross-sectional study. Two independent cardiologists assessed the scans to identify and measure the size of any pericardial effusions. The prevalence of effusions in patients undergoing low-dose oral minoxidil (LDOM) therapy was then compared with that in patients not receiving minoxidil therapy.

The following were the key findings of the study:

• A total of 100 patients were evaluated for pericardial effusion: 51 LDOM patients and 49 control patients.
• The two groups were similar in terms of age (53.7 versus 54.1), sex (86% versus 73% female), and race.
• Small pericardial effusions (<1 cm) were identified in 5.8% of LDOM patients and 6% of control patients, none of which were symptomatic.

Limitations of the study include its small size and the constraints on drawing causal inferences from confirmed cases.

"While additional studies are needed, this research did not reveal a significantly higher prevalence of pericardial effusions in alopecia patients undergoing low-dose oral minoxidil therapy compared to controls," the researchers concluded.

"The study offers encouraging news for those using low-dose oral minoxidil to manage alopecia, suggesting that it does not significantly increase the risk of pericardial effusions. As always, patients should continue to consult with their healthcare providers to monitor their health and address any potential concerns during their treatment," they wrote. 

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DOI: https://www.jaad.org/article/S0190-9622(24)01069-7/fulltext