Chronic Low Sleep Deprivation may increase risk of SLE, finds study

Results

• 186,072 women with 187 incident SLE cases during 4,246,094 person-years of follow-up were included.
• Chronic low sleep duration which is ≤5 hours/night vs reference >7-8 hours was associated with increased SLE risk, which persisted after the analysis was lagged and adjusted for shiftwork, bodily pain, and depression.
• additive interactions between low sleep duration and high bodily pain (SF-36 <75) with an attributable proportion (AP) of 64% and an HR for SLE of 2.97 for those with both risk factors compared to those with neither. 
• Similarly, there was an interaction between low sleep duration and depression with an AP of 68% and an HR for SLE of 2.82. 

Thus, the researchers highlighted the potential role of adequate sleep for disease prevention and found that chronic low sleep duration was associated with higher SLE risk, and they also added that the effect was stronger among those with bodily pain and depression. 

To read the full article, click here:  https://doi.org/10.1002/acr.25017 

Choi MY, Malspeis S, Sparks JA, Cui J, Yoshida K, Costenbader KH. Association of Sleep Deprivation and the Risk of Developing Systemic Lupus Erythematosus among Women [published online ahead of print, 2022 Sep 12]. Arthritis Care Res (Hoboken). 2022;10.1002/acr.25017.