Compared to Dupilumab Upadacitinib rapidly improves itching and clears skin in atopic dermatitis: JAMA
Written By : Dr Manoj Kumar Nayak
Medically Reviewed By : Dr. Kamal Kant Kohli
Published On 2021-08-09 03:30 GMT | Update On 2023-10-19 10:20 GMT
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Upadacitinib vs Dupilumab in adult atopic dermatitis (AD) : JAMA study
Atopic dermatitis is a severely pruritic relapsing disorder with multiple cytokines like interleukins (IL) like IL- 4, 13, 22,-31, interferon gamma (IFN-γ) and thymic stromal lymphopoietin (TSLP) involved in its pathogenesis. Dupilumab, a monoclonal antibody against α-subunit of IL-4 and IL-13 receptors is approved for the treatment of moderate-to-severe AD. Upadacitinib is an oral, reversible, selective JAK1 inhibitor recently showing evidence of efficacy in AD.2
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