Dupilumab effective against moderate-to-severe AD across all anatomic regions

In a 52-week, phase 3 clinical trial (LIBERTY AD CHRONOS) in adult patients with moderate-to-severe atopic dermatitis (AD), dupilumab in combination with topical corticosteroids (TCS) resulted in a significant improvement in overall Eczema Area and Severity Index (EASI) compared with placebo plus topical corticosteroids. In a post hoc analysis, dupilumabsignificantly improved the overall extent and severity of atopic dermatitis across four anatomic regions (head and neck, trunk, upper extremities, lower extremities) over 16 weeks. However, as atopic dermatitis severity and presentation may vary by body region, this analysis sought to determine whether there are regional variations in dupilumab efficacy.

Using data from the LIBERTY AD CHRONOS study, we performed a post hoc analysis of the mean percentage change in individual EASI signs (erythema, infiltration/papulation, excoriation, lichenification) from baseline through week 52 across four anatomic regions (head and neck, trunk, upper extremities, lower extremities).

Results:

Dupilumab plus topical corticosteroids, compared with placebo plus topical corticosteroids, significantly improved the severity of all individual atopic dermatitis signs to a similar extent across the four anatomic regions. Significant improvements in each sign were seen early, within the first 2-4 weeks of treatment, and were sustained through week 52 across all regions.

Thus, in adult patients with moderate-to-severe atopic dermatitis, treatment with dupilumab resulted in rapid and sustained improvement in the signs of atopic dermatitis across all anatomic regions.

Reference:

Blauvelt A, de Bruin-Weller M, Simpson EL, Chen Z, Zhang A, Shumel B. Dupilumab with Topical Corticosteroids Provides Rapid and Sustained Improvement in Adults with Moderate-to-Severe Atopic Dermatitis Across Anatomic Regions Over 52 Weeks. Dermatol Ther (Heidelb). 2022 Jan;12(1):223-231. doi: 10.1007/s13555-021-00638-1. Epub 2021 Nov 22. PMID: 34806137; PMCID: PMC8776906.

Keywords:

Blauvelt A, de Bruin-Weller M, Simpson EL, Chen Z, Zhang A, Shumel B, Dupilumab, Topical Corticosteroids, Provides, Rapid, Sustained, Improvement, Adults, Moderate-to-Severe, Atopic, Dermatitis, Across, Anatomic, Regions, 52 Weeks, Dermatology and Therapy