Metronidazole reasonable treatment option for patients with symptomatic oral lichen planus
USA: A recent study published in Clinical and Experimental Dermatology has shown metronidazole to be a reasonable option for patients with symptomatic oral lichen planus (OLP) who have failed topical treatment options.
The researchers suggested metronidazole to be a reasonable option given its efficacy, mild side effect profile, and less immunosuppressive nature as compared to alternative systemic treatment options.
At least partial response was seen in 60.0% of the patients treated with metronidazole 500 mg twice daily, with complete response noted in 33.3% of the patients.
Lichen planus is an inflammatory dermatosis with mucosal variants, including oral lichen planus. OLP has relapsing chronic courses and may have a significant impact on quality of life. Following approval from the FDA's Institutional Review Board (IRB), Alison N Hollis, University of North Carolina at Chapel Hill, North Carolina, USA, and colleagues analyzed metronidazole's efficacy as a treatment for oral lichen planus by retrospective chart review of patients at the institution over 10 years with a diagnosis of OLP. The study included patients with concomitant use of topical treatments.
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