Sleep and Testosterone: Dual Drivers of Psoriasis Risk in Men: Study
Men with low testosterone levels below 300 ng/dL are twice as likely to develop psoriasis (OR 2.97), while sleep less than 7 hours was associated with a 76% higher risk, according to NHANES data. Risk diminished at very low testosterone levels and beyond 8 hours of sleep, highlighting hormonal balance and sleep as modifiable risk factors in psoriasis prevention.
Psoriasis is a chronic, multisystemic immune-mediated inflammatory disorder with a complex etiology involving genetic, environmental, and systemic factors. Testosterone, a key androgen hormone, has immunomodulatory effects, and its deficiency is linked to increased inflammation. Sleep disturbances are also known to exacerbate systemic inflammation. This study investigates the associations between low testosterone levels, short sleep duration, and psoriasis risk using data from the US National Health and Nutrition Examination Survey (NHANES) 2011– 2014.
This cross-sectional study included 4,060 male participants, after excluding individuals with missing data on psoriasis, testosterone, sleep duration, and relevant covariates. Psoriasis status was self-reported, testosterone levels were measured using isotope-dilution liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS), and sleep duration was assessed through a self-reported questionnaire. Multivariable logistic regression models were used to estimate the associations between testosterone levels, sleep duration, and psoriasis risk. Restricted cubic spline (RCS) analysis explored potential non-linear relationships, and subgroup and sensitivity analyses were performed to test the robustness of the findings.
Disclaimer: This website is primarily for healthcare professionals. The content here does not replace medical advice and should not be used as medical, diagnostic, endorsement, treatment, or prescription advice. Medical science evolves rapidly, and we strive to keep our information current. If you find any discrepancies, please contact us at corrections@medicaldialogues.in. Read our Correction Policy here. Nothing here should be used as a substitute for medical advice, diagnosis, or treatment. We do not endorse any healthcare advice that contradicts a physician's guidance. Use of this site is subject to our Terms of Use, Privacy Policy, and Advertisement Policy. For more details, read our Full Disclaimer here.
NOTE: Join us in combating medical misinformation. If you encounter a questionable health, medical, or medical education claim, email us at factcheck@medicaldialogues.in for evaluation.