Thalidomide may reduce flare frequency in patients with chronic Erythema Multiforme: JAMA
Thalidomide therapy was associated with a high rate of remission and a reduction in flare frequency in patients with Chronic Erythema Multiforme, according to a recent study published in the JAMA Dermatology.
Erythema multiforme (EM) may become long term, with a recurrent or persistent course. First-line treatment for chronic EM is valaciclovir. There is no consensus for selection of second-line treatment of chronic EM. The aim of this study was to assess the effectiveness of treatment with thalidomide for patients with chronic EM.
In this retrospective national multicenter cohort study, among 68 French hospital dermatology departments contacted by e-mail, 10 reported having eligible cases. All adults aged 18 years or older under dermatology care for chronic EM (including recurrent and persistent forms) who had received thalidomide between 2010 and 2018 were included. Analyses were conducted from June 24, 2019, to December 31, 2019. The primary outcome was the proportion of patients who did not experience an EM flare within 6 months of initiating thalidomide treatment for recurrent EM or with complete clearance at 6 months for persistent EM (complete remission).
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