Topical application of Azelaic acid may improve cosmetic manifestations in rosacea, acne and melasma
Topical azelaic acid is effective for managing rosacea, acne and melasma, says Dr Sarah King in his study published in the Journal of Cosmetic Dermatology.
The co-author of this study "A systematic review to evaluate the efficacy of azelaic acid in managing acne, rosacea, melasma and skin ageing" is Dr Jo Campbell. AA is indicated for treating acne and rosacea, but there needs to be more research on its effectiveness in other dermatological conditions.
In this study, researchers aimed to determine the effectiveness and safety of topical AA for acne vulgaris, rosacea, hyperpigmentation/melasma, and skin ageing by reviewing RCTs of at least six weeks' treatment from Databases like MEDLINE, Embase, CINAHL, and ClinicalTrials.gov (up to December 2022).
Forty-three RCTs met the inclusion criteria.
Considering Meta-analyses within 20 rosacea studies, it was found that on treatment with AA, there was a significant improvement in manifestations like erythema severity, inflammatory lesion counts, overall improvement, and success in attaining skin clarity after 12 weeks compared to vehicle.
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