Topical Skincare Regimen may Reduce Erythema and Hyperpigmentation Post-CO2 Laser Treatment, reveals study
Researchers have found that using a topical skincare regimen containing CE Ferulic serum and Resveratrol BE night serum (CEF-RBE) significantly reduces erythema and hyperpigmentation following ablative fractional CO2 laser treatment. Recently a study was published in Journal of the European Academy of Dermatology and Venereology: JEADV which was conducted by Yu Shi and colleagues. This study, conducted on a Chinese population, demonstrates the efficacy and safety of this regimen in improving post-treatment skin recovery and overall patient satisfaction.
Ablative fractional CO2 laser is a popular treatment for various skin issues, but it often leads to adverse effects like erythema, dyspigmentation, and extended recovery periods, which negatively impact patients' quality of life. This study aimed to evaluate whether a regimen of CE Ferulic and Resveratrol BE serums could mitigate these adverse effects and promote better skin healing.
This randomized, investigator-blinded, split-face, controlled trial involved 51 patients aged 18 to 65 undergoing ablative CO2 laser treatment. Participants were randomly assigned to apply the CEF-RBE regimen to one side of their face and normal saline (NS) to the other side for 14 consecutive days. The regimen included applying CE Ferulic plus resveratrol BE serum to the designated side of the face twice daily, while the other side received normal saline. The primary endpoint was the erythema index (EI) on day 14. Key secondary endpoints included scabbing detachment time, percentage changes in EI and melanin index (MI), skin hydration, transepidermal water loss, skin sebum content, edema, and overall subject satisfaction.
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