1-hour plasma glucose useful tool for predicting risk of hepatic fibrosis
USA: 1-hour plasma glucose (1-h PG) is a useful tool for distinguishing subjects with normal glucose tolerance (NGT) or impaired fasting glucose (IFG) at increased risk of hepatic fibrosis needing further evaluation with elastography, research finds. The study appears in Diabetes Research and Clinical Practice on June 27, 2022.
People with high 1-hour plasma glucose (1-h PG>155mg/dl;8.6mmol/l) during an oral glucose tolerance test have been reported to be at increased risk of type 2 diabetes (T2D) and cardiovascular complications, mortality, and hepatic steatosis. However, there is no clarity on the clinical relevance of 1-h PG for the severity of hepatic fibrosis risk.
Ram Jagannathan, Department of Medicine, Division of Hospital Medicine, Emory University School of Medicine, Atlanta, GA, USA, and colleagues used cross-sectional data of the CATAMERI study (n=2335). Participants underwent liver enzyme determinations, anthropometric measurements, cardiometabolic profiling, and a 75-gram oral glucose tolerance test, including fasting, 1-h, and 2-h PG determinations, and measurement of FIB-4 score to assess the degree of hepatic fibrosis. The risk of advanced hepatic fibrosis with worsening glycemic status was evaluated using multivariable logistic regression analysis.
Key findings of the study include:
· Study group was stratified into 6 categories based on glycemic status: normal glucose tolerance (NGT) 1h-PG Low, NGT 1h-PG High, iIFG 1h-PG Low, iIFG 1h-PG High, IGT, and newly detected T2D.
· Anthropometric and cardiometabolic profiles worsened gradually with glycemic status.
· Compared to NGT-1h-PG Low group, worsening glycemic status was significantly associated with the severity of fibrosis, independent of other significant clinical risk factors.
The researchers concluded by saying, "1-PG is a valuable tool for stratifying subjects with NGT or IFG at heightened risk of hepatic fibrosis requiring further evaluation with elastography."
Reference:
The study titled, "One-Hour Post-load Glucose is Associated with Severity of Hepatic Fibrosis," was published in the journal Diabetes Research and Clinical Practice. DOI: https://doi.org/10.1016/j.diabres.2022.109977
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