Add on pioglitazone effective for type 2 diabetes patients with alcoholic fatty liver disease

Japan: Pioglitazone could also be an effective treatment option for type 2 diabetes (T2D) patients with alcoholic fatty liver disease (AFLD), a recent study has suggested.
Findings from the retrospective single-centre trial, published in Diabetology International, found that pioglitazone dose did not impact weight gain but notably reduced HbA1c level in patients with or without fatty liver (FL). In patients with fatty liver disease, the decrease in HbA1c level was significantly more pronounced compared to those without fatty liver disease.
NAFLD (Non-alcoholic fatty liver disease) and type 2 diabetes share pathophysiological mechanisms and possible therapeutic strategies. Pioglitazone, an antidiabetic medication used for treating type 2 diabetes, improves function in type 2 diabetes patients with alcoholic fatty liver disease; however, there is no clarity on its efficacy in type 2 diabetes complicated with alcoholic fatty liver disease. Therefore, Masahiro Asakawa and colleagues from Japan investigated whether pioglitazone ameliorates liver dysfunction in type 2 diabetes patients with AFLD in a retrospective single-centre trial.
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