Afternoon exercise best for blood sugar control in those at diabetes risk: Study
The circadian clock and metabolism are tightly intertwined. Hence, the specific timing of interventions that target metabolic changes may affect their efficacy.
Researchers have found in a new study that individuals at risk of diabetes who exercised in the afternoon had better blood sugar control and lost more belly fat compared to those who exercised in the morning. Men at high risk of type 2 diabetes who worked out between 3 p.m. and 6 p.m. for 12 weeks significantly improved their average insulin sensitivity, which helped them have better blood sugar control, compared with those who worked out between 8 a.m. and 10 a.m. The findings suggest that the timing of an exercise training session is a crucial environmental cue when aiming to improve blood sugar control in metabolically compromised subjects and elucidates that performing afternoon exercise training might be more optimal than exercising at morning hours.
The research has been published in the journal Physiological Reports on 23 December 2020.
The circadian rhythmicity is regulated by a central clock, which is located in the hypothalamic suprachiasmatic nucleus (SCN), but also by multiple peripheral molecular clocks, located in distal organs such as skeletal muscle, liver, and adipose tissue. While the central clock is entrained by daily light-dark cycles, the peripheral molecular clocks are robustly entrained by non‐photic environmental signals (zeitgebers) such as exercise and feeding. Previous studies have shown that a rapid day-night shift, as a model for shiftwork or jetlag, leads to disturbed glucose homeostasis and skeletal muscle insulin resistance in humans, illustrating the indisputable role that central and peripheral molecular clocks play in regulating systemic energy homeostasis. As such, integrating different external cues at optimal times can potentially be used to improve metabolic health. However, the effect of the timing of exercise was not previously analyzed. Therefore, researchers of the Maastricht University Medical Center, Netherlands, conducted a study to compare the metabolic health effects of morning versus afternoon exercise training in metabolically compromised subjects enrolled in a 12‐week exercise training program.
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