Benefits of Liraglutide and sitagliptin not linked to gut Microbiata changes: Study

Intestinal microbes are critical for many biological processes in the human body, including digestion, glucose metabolism, immunomodulation and gut barrier function.
A recent study suggests that liraglutide and sitagliptin have effects on glucose metabolism, body weight and bile acids, when used as add-on therapies to metformin or sulphonylureas, however, it shows no changes in the intestinal microbiota. The research has been published in the journal Diabetes & Metabolism on January 08, 2021.
Intestinal dysbiosis, with its reduced bacterial load and diversity, has extensively been linked to the development of obesity and its related disorders, such as insulin resistance and type 2 diabetes (T2D). Modulation of intestinal microbiota could therefore be a tool to prevent or reduce symptoms of these highly prevalent metabolic conditions. Preclinical data suggest that treatment with either glucagon-like peptide (GLP)-1 receptor agonists or dipeptidyl peptidase (DPP)-4 inhibitors could change the intestinal microbiome and thereby contribute to their beneficial (cardio)metabolic effects. Therefore, Dr Mark M.Smits of Amsterdam University Medical Center, Netherlands and colleagues conducted a study to investigate the effects of these agents on microbiota composition in adults with type 2 diabetes (T2D).
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